Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...
Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding the ...
Historically, these factors have made the identification of proteins incredibly challenging. The advent of mass spectrometry (MS) and MS-based proteomics helped to change that. 2 MS is an analytical ...
The team, from biopharmaceutical company Regeneron, hopes their work will help researchers better understand protein-protein interactions during preclinical development of a drug. “Essentially, we ...
A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...
This episode of the Pharmaron DMPK Insights Podcast Series features Scott Summerfield (Executive Director of Metabolism at Pharmaron) and John Mehl (consultant and previous director at GSK, and ...
As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...
Many proteins contain patterns of sugar molecules (glycans) and are made of several aggregated subunits. This glycosylation and oligomerization has a decisive influence on protein function and must be ...
A new prototype could supercharge mass spectrometry by analyzing thousands of molecules at once instead of one by one. The ...
Morning Overview on MSN
Rockefeller prototype mass spectrometer analyzes 1B molecules at once
Scientists at The Rockefeller University have built a prototype mass spectrometer that can process over a billion molecules ...
Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.
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