How does the ER prevent misfolded proteins? Researchers identify the SLC33A1 transporter as a critical glutathione regulator for protein quality control.

In the past several years, Rockefeller University's Kivanç Birsoy and his team in the Laboratory of Metabolic Regulation and ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When ...

Hyderabad, have identified a mammalian protein, Cnpy1 (Canopy1), that is essential for the survival and function of ...

What is the Cnpy1 protein? New research reveals how the Canopy1 protein allows vomeronasal neurons to survive high ER-stress.

What is the endoplasmic reticulum? The endoplasmic reticulum is the single largest membrane-bound organelle found inside eukaryotic cells. Its complex structure containing tubules, sheets, and ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

Rockefeller researchers previously discovered several new important tasks that the antioxidant glutathione manages throughout the body. Now they’ve found that glutathione maintains the smooth ...