From payload optimization to integrated GMP manufacturing, companies aim to elevate oncology ADCs to standard of care.

With the precision of monoclonal antibodies and the potency of small-molecular payloads, antibody-drug conjugates (ADC) are promising cancer therapeutics. As of this year, there are 19 ADC drugs ...

Developers often treat payload selection, conjugation chemistry and commercial scale-up as isolated operations. This ...

This novel approach utilizes cysteine-engineered antibodies which allows for the development of uniform and homogenous ADCs with precise control of the drug to antibody ratio (DAR). The drug-payload, ...

For instance, recent work has highlighted the potential to increase antigen availability through the use of statin 21 or increase internalization and lysosomal sorting through the use of kinase ...

BioNTech is putting its COVID-19 vaccine dollars to work to add a new modality to its pipeline. Sitting on $15 billion, the German biotech has doled out $170 million upfront for the rights to two ...

SUZHOU, China--(BUSINESS WIRE)--Thousand Oaks Biologics Inc. (TOBio) and GeneQuantum Healthcare (Suzhou) Co., Ltd. (GQ) are pleased to announce that they have formed a strategic partnership focusing ...

PRINCETON, N.J., Feb. 19, 2025 (GLOBE NEWSWIRE) -- Sonnet BioTherapeutics Holdings, Inc. (SONN), a clinical-stage company developing targeted immunotherapeutic drugs, today announced its plans to ...